IP: 54.36.148.120
.
Advanced search
Collection by: Publisher Title

Study of intracellular signaling pathways in chronic myeloproliferative neoplasms - Martinelli, Serena - Firenze : Firenze University Press, 2017.Monograph
Sample pageSample page
Catalog
Firenze University Press
Martinelli, Serena

Study of intracellular signaling pathways in chronic myeloproliferative neoplasms

Firenze : Firenze University Press, 2017.
ID: 4335087
Permalink: http://digital.casalini.it/9788864535654
ISBN: 9788864535654
Description
  • 75 p. : ill.
Series
Notes
  • A gain-of-function mutation in Janus kinase 2 (JAK2V617F) is at the basis of the majority of chronic myeloproliferative neoplasms (MPN). Enhanced activation of other downstream pathways including the PI3K/mTOR pathway has been documented as well. In this study we evaluated the effects of JAK1/2 inhibitors, alone and in combination with mTOR, with a dual mTOR/PI3K inhibitor and with a pan PI3K inhibitor in in-vitro and in-vivo MPN models. Our findings of strong synergy between the JAK2 inhibitors and mTOR/PI3K inhibitor suggested that we might be able to administer these drugs at lower concentrations than when the drugs are used individually. This provides a framework for combination trials using compounds in patients with myeloproliferative neoplasms.
  • Serena Martinelliobtained the PhD title in Biomedical Science at Florence University in 2016. She is co-author in several articles and she is listed as the leading author in one of them. Her technical skills and competences are cellular biology, molecular biology and mouse models. [Publisher's text].
  • Includes bibliographical references.
Topics
  • DiseasesDDC: 616
  • Internal MedicineLCC: RC
Sample PageStudy of intracellular signaling pathways in chronic myeloproliferative neoplasms - [Martinelli, Serena] - [Firenze : Firenze University Press, 2017.]
La mente si ammalaLa mente si ammala
La maternità possibile : i vissuti delle coppie sterili, la fede e la procreazione assistitaLa maternità possibile : i vissuti delle coppie sterili, la fede e la procreazione assistita
La cura di sé in contesti terapeutici non convenzionaliLa cura di sé in contesti terapeutici non convenzionali
Psicoterapie integrative : alleanza ed esperienze correttive per terapie personalizzatePsicoterapie integrative : alleanza ed esperienze correttive per terapie personalizzate
Medicina narrativa in Terapia Intensiva : storie di malattia e di curaMedicina narrativa in Terapia Intensiva : storie di malattia e di cura
Firenze University Press
Complete work
Study of intracellular signaling pathways in chronic myeloproliferative neoplasms
Copyright 2000-2017 Casalini libri
VAT no. IT03106600483